Amphophil tumors of the hypophysis induced in mice by I131.

It is often implied that chromophobe adenomas of the hypophysis are without significant endo crine function (11). However, some hypophyseal tumors experimentally produced in mice by de stroying their thyroids with I131 have been de scribed as functioning chromophobe adenomas (9, 10). A review of the literature on the effects of thy roid deficiency in laboratory animals reveals wide discrepancies in the hypophyseal changes re ported. Most workers agree that the hypophysis becomes hyperplastic and increases in weight and that there is a marked reduction in the relative percentage of acidophils. However, the hyperplastic cells are regarded as "basophils" by some workers and as "chromophobes" by others. Some